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Monday, May 11, 2020 | History

2 edition of The therapeutic use of digitalis found in the catalog.

The therapeutic use of digitalis

by George Canby Robinson

  • 351 Want to read
  • 19 Currently reading

Published by Williams & Wilkins in Baltimore .
Written in English


Edition Notes

SeriesMedicine monographs, v. 2
Classifications
LC ClassificationsRM666 D5 R6
The Physical Object
Pagination137p.
Number of Pages137
ID Numbers
Open LibraryOL24429822M

THERAPEUTIC DRUG MONITORING Therapeutic drug monitoring (TDM) is the use of drug concentration measurements in body fluids as an aid to the management of drug therapy for the cure, alleviation or prevention of disease. 1 It has long been customary to adjust the dosage of . The use of digoxin therapy for the treatment of atrial fibrillation has also decreased as alternative therapies with greater efficacy and reduced toxic effects have been developed. Different digoxin products have significant bioavailability differences. Many drugs interact with digoxin, often requiring an adjustment of the digoxin dose.

toxicity with digoxin concentrations mcg/L.7–9 For patients on digoxin for atrial fibrillation, the goal for digoxin is rate controlRate con-trol is achieved by atrioventricular (AV) nodal blockade and may require higher digoxin concentrations. The use of pharmacokinetics to adjust theFile Size: KB. Digoxin is a curious drug with an unusual history. The use of digitalis genus plants was first described in by British physician Dr. William Withering, for the treatment of edema (“dropsy”) and other peculiar conditions [(1)][1]. Following the advent of isolation of digoxin from the.

Digitalis lanata is the major source of digoxin in the US. Foxglove is most commonly used for congestive heart failure (CHF) and relieving associated fluid retention irregular heartbeat. It is not. Digitalis is used to treat congestive heart failure (CHF) and heart rhythm problems (atrial arrhythmias). Digitalis can increase blood flow throughout your body and reduce swelling in your hands and ankles. How does digitalis work? Digitalis medicines strengthen the force of the heartbeat by increasing the amount of calcium in the heart’s cells.


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The therapeutic use of digitalis by George Canby Robinson Download PDF EPUB FB2

Texts All Books All Texts latest This Just In Smithsonian Libraries The therapeutic use of digitalis by Robinson, George Canby, Publication date Topics Digitalis (Drug) Publisher Baltimore Williams & Wilkins Collection gerstein; toronto Digitizing sponsor Internet Archive Contributor Gerstein - University of Toronto Language Pages: Additional Physical Format: Online version: Robinson, George Canby, Therapeutic use of digitalis.

Baltimore, Williams & Wilkins company, Digitalis has been known since the Middle Ages and used mainly by external application. Oral application, however, was mentioned before William Withering.

The priority of publication of the use of digitalis in dropsy is discussed between William Withering and Erasmus by: 1. Clinical Use of Digitalis: A State of the Art Review. Whayne TF Jr(1). Author information: (1)Gill Heart and Vascular Institute, University of Kentucky, Wethington Building, South Limestone Street, Lexington, KY,USA.

[email protected] The history of digitalis is rich and interesting, with the first use usuallyattributed to William Withering and his study on the foxglove published in Cited by: 7.

The administration of digitalis in adequate therapeutic amounts and without producing untoward toxic effects may present many problems. It is important for the practitioner of medicine to understand the principles involved in the proper employment of this drug.

The history of digitalis is rich and interesting, with the first use usually attributed to William Withering and his study on the foxglove published in However, some knowledge of plants with digitalis-like effects used for congestive heart failure (CHF) was in evidence as early as Roman times.

The active components of the foxglove (Digitalis purpurea and Digitalis lanata) are classified Cited by: 7. A.D. Woolf, F.H. Lovejoy Jr, in Human Toxicology, The toxicity of digitalis has undoubtedly declined since then due to several compelling reasons: (i) with a more clearly defined role for digitalis in the management of congestive heart failure and arrhythmias, supplemented by other effective cardiovascular agents, therapeutic changes allow for a lower effective digoxin dose; (ii) careful.

Drugs that interact with digitalis, that raise serum digitalis levels, and that could contribute to digitalis toxicity include certain antibiotics (e.g., tetracycline and erythromycin) and antiarrhythmics (quinidine, flecainide, amiodarone, and verapamil).

Clinical Use of Digitalis: A State of the Art Review it has been modified but not relegated to the garden or the medical history book, as some would advocate.

The use of digoxin in the. List of Monitorable Drugs and Therapeutic Ranges 5 Basic Pharmacokinetic Concepts 7 Guidelines for Pharmacokinetic Monitoring 14 General Equations for BSA, IBW, and Clcr 16 Monitorable Drugs Aminoglycosides – Conventional Dosing 19 Aminoglycosides – High Dose Extended Interval 30 Carbamazepine 40 Digoxin 43 Lidocaine 50 Lithium   The fundamental therapeutic action of digitalis is stimulation of ventricular contractile state.

The expression of this increased contractility is dependent on the integrity of cardiocirculatory status when the glycoside is by: Digoxin is a drug that belongs to a group of drugs called cardiac glycosides.

It has a positive inotropic (increases the strength of your hearth) and negative chronotropic effect (slows down your heart rate).It is ssed in the treatment of chronic heart failure and atrial fibrillation. The therapeutic use of digitalis was first described in the late 18th century, when it was used to treat edema, a condition associated with heart failure.

Derek Fell Get exclusive access to content from our First Edition with your subscription. The use of digoxin is limited because the drug has a narrow therapeutic index and requires close monitoring.

Digoxin can cause many adverse events, is involved in multiple drug interactions, and can result in toxicity. Despite its limitations, however, digoxin has a place in therapy. OCLC Number: Description: ix, pages illustrations: Contents: Introductory remarks --The action and clinical use of digitalis --Digitalis intoxication --Electrolytes and digitalis --Relation of potassium to digitalis intoxication --Paroxysmal atrial tachycardia with block --A digitalis tolerance test sibility: by Bernard Lown and Samuel A.

Levine. Search the world's most comprehensive index of full-text books. My library. Digoxin, also called digitalis, helps an injured or weakened heart pump more efficiently. It strengthens the force of the heart muscle's contractions, helps restore a normal, steady heart rhythm. Digitalis is an example of a cardio-active or cardiotonic drug, in other words a steroid which has the ability to exert a specific and powerful action on the cardiac muscle in animals, and has been used in the treatment of heart conditions ever since its discovery in The discovery of digitalis is accredited to the Scottish doctor William Withering, and makes for quite an interesting.

Digitalis (/ ˌ d ɪ dʒ ɪ ˈ t eɪ l ɪ s / or / ˌ d ɪ dʒ ɪ ˈ t æ l ɪ s /) is a genus of about 20 species of herbaceous perennials, shrubs, and biennials commonly called foxgloves. This genus was traditionally placed in the figwort family Scrophulariaceae, but recent phylogenetic research has placed it in the much enlarged family Plantaginaceae.

This genus is native to western and Family: Plantaginaceae. Toxicity and Overdose: Therapeutic serum digoxin levels rangefrom–2 ng/evelsmaybedrawn6–8hrafteradoseisadministered,although theyare usually drawn iaintheGItractFile Size: KB.

Bupropion; Naltrexone: (Moderate) Plasma digoxin concentrations and the patient's clinical response to digoxin therapy should be monitored during concurrent use with bupropion, due to the potential for decreased systemic exposure to digoxin.

When a single oral dose of mg of digoxin was administered 24 hours after a single mg oral dose of extended-release bupropion in healthy volunteers, the .Cardiac glycosides have played a prominent role in the therapy of congestive heart failure since William Withering codified their use in In view of its narrow therapeutic index, limited published data on efficacy in children, and the widespread availability of newer drugs like angiotensin-converting enzyme (ACE) inhibitors and beta blockers, many clinicians have started questioning the role of .The Therapeutic Use of Stories provides a sound theoretical framework for the use of stories, examples of stories with a high therapeutic value, and practical advice on how to use them to best effect.

Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. 2/5(1).